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Figure generated with Slicer software and demonstration data. Using glycosylation of an indicator peptide as a marker of transport into the endoplasmic reticulum, and using competition with other peptides, investigators showed that the sequence specificity of the TAP complex is much broader than the binding specificity of MHC class I molecules (291), as could be expected because the same TAP molecules must function with multiple class I MHC molecules.
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