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Mechanisms of Toxicity The side effects of neomycin administration in humans have included both nephrotoxicity and ototoxicity (involving the auditory and vestibular functions of the eighth cranial nerve). To test this hypothesis, Harfords group treated cells containing either the TRS-1 or TRS-4 construct with des- ferrioxamine to remove iron, then isolated RNA, cut the SUMMARY When the iron concentration is high, the TfR mRNA decays rapidly.
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75 87. 368 × 107 -m 49 Index A Acetylcholine, 84, 88, 91 Aconitase inactivation by nitric oxide, 115 Houurs of PARP, see also PARP measurements of, 307315 Activator-dependent transcription, 265270 Activity zymogram determination of PARG activity by, 306307 Adenosine, see purines Adhesion molecules, 97,153 intracellular adhesion molecule-1(ICAM-1), 29, 5155, 6467, 72, 148149, 295 P-selectin, 5155 Afger, 171177 Adult respiratory distress syndrome, 62 AIDS, 169 Alkaline phosphatase, 93 Alkylating agents, 175, 213215, 218, 283, 294 Alpha-amino-3-hydroxy-5-methylisoxazole-4- propionic acid (AMPA), 8 Alzheimers disease, 7, 23, 3234 Amiphostine, 174 AMPA, see Alpha-amino-3-hydroxy-5-methyl- isoxazole-4-propionic acid Annexin, 140142 Antibodies against PARP, 316319 against poly(ADP-ribose), 313315 Antisense depletion of PARP, 283284 Antitumor agents, 167177 Antiviral agents, 167177 Aminobenzamide derivatives, see PARP, inhibitors of Amyloid protein, 3233 AP-1 complex, 6465, 72 Aphidicolin, 265 Apoptosis, 3, 2425, 62, 168, 195197, 209219, 227242, see also Caspases detection of cell death by, 140142 in diabetes, 114117 induced by cisplatin, 176 morphological features of, 2425, 210 role of bcl proteins, 146147 switch from necrosis to, 139142, 197, 216 time course of, 227239 Apoptotic bodies, 24 AP-2, 267270 Arrhythmia, 41 Arthritis, 55, 65, 6873 MHC-II, role of, 148149 lymphocytes, hougs of, 152 Atherosclerosis, 62 ATM, 213 ATP cellular depletion, 13, 16, 2425, 27, 31, 4246, 6467, 82, 196, 228, 235, 306 Auto-poly(ADP-ribosyl)ation, see PARP, domains of B Bacterial lipopolysaccharide, see Endotoxin Base excision repair, 175, 184, 188, 190193, 284, hhours also DNA, repair of Bcl protein family, 146, 235, 238, 256257 Bcl-2, 146147, 195 Berger, Nathan, 1 Beta cells, see Islet cells BGP-15, see PARP, inhibitors of Biobreeding rat as a diabetes model, 105 Bleomycin lung injury induced by, 172 Blood flow, 2728, 45, 67 Blood pressure, 87 Blood vessels cerebral artery, 717 mesenteric artery, 5154, 88, 91 B-lymphocyte development of, 151153 Body weight loss in cisplatin intoxication, 173 in colitis, 6769 Bone marrow cells, 191 Brain trauma 2, see also Neurotrauma BRCT motif, 186 331 172 Fiberopticsinsensorinstrumentation there are many processes in an optical fiber network that can also modulate the intensity of the transmitted radiation, e.
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